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The s Drug Market And The Treatment Of Alzheimer s...

Razadyne or Galantamine is an alkaloid drug used mainly in the treatment of Alzheimer’s disease and dementia. It works through the mechanism of reverse competitive inhibition of the enzyme called acetylcholinesterase, which prevents the breakdown of the correspondent substrate acetylcholine, an essential chemical for the processes of thinking and reasoning. The Alzheimer’s drug market represents a 5.5-billion-dollar industry according to a pharma matters report published in 2009 by Thompson Reuters. However, Galantamine only owns a small percentage of this market, which requires an improvement in the current manufacturing process in order to compete with the other pharmaceutical companies who own the greater portions of the Alzheimer’s†¦show more content†¦Table of Contents Market Development Plan Chemical Description and Commercial Use†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦1 Alzheimer’s Market†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..2 Alzheimer’s Competitors†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.3 Galantamine Competitors†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦....4 Cost Estimation for the Production of Galantamine†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦5 Reaction Chemistry and Process Improvement Reaction Scheme for the Production of Galantamine†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.†¦....7 Reaction Temperatures and Solvents†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦....8 List of Potential By-products†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...9 Block Flow Diagram for the Production of Galantamine†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..10 Technical Challenges†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.11 Recommendations and Potential Profit Increase†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦12 Conclusion†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..13 Literature Cited†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..14 Appendix: Calculations†¦Ã¢â‚¬ ¦..†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦16 List of Figures Figure 1. Three Dimensional Structure of Galantamine†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..1 Figure 2. Sales Figures (2000 to 2011) and Consensus Forecast Sales†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦...3 Figure 3. Reaction Scheme for the Overall Production of Galantamine†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.7 Figure 4: Block Flow Diagram for the Production Galantamine from 3,4-Dimethoxybenzaldehyde†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦10 List of Tables Table 1. Market Demand of Possible Galantamine Applications†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦....3 Table 2. Average Consumer Cost

The Cask Of Amontillado By Edgar Allan Poe - 1381 Words

Everybody has at one point been insulted, or insulted someone. The reaction to this many times is simply an argument, but it can lead to more serious ramifications. In literature, characters may take serious offense to an insult, and consider it a serious obstacle, vowing to retaliate. In Edgar Allan Poe’s â€Å"The Cask of Amontillado†, Montresor must overcome a hindrance, one that he establishes to be of vital importance. Fortunato, someone of a similar wealthy stature as that of Montresor, acted in a way that could not be tolerated after he insulted Montresor. In reaction to this, Montresor decides to lure Fortunato into his family tomb under the false pretense of Amontillado, a type of wine, chains him to a niche in the deepest recess of the catacombs and buries him while he is still living. Characters in literature overcome obstacles by manipulating their opponents, using logic and by taking advantage of their surroundings. Montresor uses manipulation so that Fortunato can be punished. For example, in the period before Fortunato s murder, Montresor continues to act in a friendly manner in his interactions with Fortunato, smiling â€Å"in his face, and [Fortunato] did not perceive [Montresor s] smile now was at the thought of [Fortunato’s] immolation†(7). To make his plan possible, Montresor has to keep Fortunato oblivious to his scheme, so by acting in a way that seemed normal, he manipulates Fortunato to his benefit. To achieve what he craves, Montresor conducts himself in aShow MoreRelatedThe Cask of Amontillado by Edgar Allan Poe888 Words   |  4 PagesThe Cask of Amontillado by Edgar Allan Poe In ?The Cask of Amontillado?, Edgar Allan Poe takes us on a trip into the mind of a mad man. Poe uses certain elements to convey an emotional impact. He utilizes irony, descriptive detail of setting, and dark character traits to create the search of sinful deceit. Poe also uses first person, where the narrator is the protagonist who is deeply involved. The purpose is to get the reader to no longer be the observer. He wants them to see with MontressorRead MoreThe Cask of Amontillado by Edgar Allan Poe836 Words   |  3 Pagesqualities in the story. In the story many things are used as symbols such as the actual cask of amontillado, the trowel, the jester costume and the setting in which there is two in the story. Another literary technique used significantly in the story is irony. Irony is the expression of ones meaning by using language that normally signifies the opposite. In the short story â€Å"The Cask of Amontillado,† Montresor a very troubled man who plans to seek revenge on another man named FortunatoRead MoreEdgar Allan Poe And The Cask Of Amontillado1384 Words   |  6 PagesWhat makes Edgar Allan Poe work unique? Other than being a strange individual, Poe has become a remarkable literature writer. The Raven, Annabel Lee, and The Cask of Amontillado are just a few of Poe’s work that staples the theme of gothic literature. This essay will allow you to see the gothic elements Edgar Allan Poe uses through his most common poems. Gothic literature has many elements which play into its definition. The actual definition is a style of writing that is characterized by elementsRead MoreThe Cask Of Amontillado By Edgar Allan Poe906 Words   |  4 Pages â€Å"The Cask of Amontillado† â€Å"The Cask of Amontillado† was written in 1846, by Edgar Allan Poe. Born in 1809, Poe never knew any of his parents. At the age of three, his mother died of tuberculosis, and his father deserted the family before he was born. Taking care of him was his foster parents in Richmond, Virginia. They loved Poe, but were not supportive of his decisions and kept Poe poor. Having debt and not being able to provide food and clothes for himself caused Poe to quit school. Later, heRead MoreThe Cask Of Amontillado By Edgar Allan Poe920 Words   |  4 Pageswhen that trust no longer exists? In â€Å"The Cask of Amontillado† written by Edgar Allan Poe, Fortunato is about to find the answer to this question. On the surface, Montresor seems friendly with Fortunato, but deep down he feels nothing but hate for him. Could this hatred have an irrationality that only Montresor understands? In different ways, both of these men are proud and affluent, yet both have downfalls that will l ead to a tragic ending. Edgar Allan Poe’s use of language contributes to the understandingRead MoreThe Cask Of Amontillado By Edgar Allan Poe1555 Words   |  7 PagesIn his writing, Edgar Allan Poe has multiple uses of direct and indirect characterization. In The Cask of Amontillado, Montresor had rules such as â€Å"I must not only punish but punish with impunity. A wrong is unredressed when retribution overtakes its redresser. It is equally unredressed when the avenger fails to make himself felt as such to him who has done the wrong† (Poe, 2). Poe used indirect characterization to show the reader that Montresor is an unreliable narrator because he justified hisRead MoreThe Cask Of Amontillado By Edgar Allan Poe1303 Words   |  6 PagesIn Edgar Allan Poe’s â€Å"The Cask of Amontillado,† the narrator recalls an extremely significant time in his life, and takes the reader along with him. Throughout the story, one experiences a perfectly planned murder which took place over fifty years ago, and still no one has discovered what truly happened to poor Fortunato as he was chained to a wall in a room that was then closed off, and torched to death due to all the nitre in the walls. As the story goes on, the reader can see some of Poe’s unfortunateRead MoreThe Cask Of Amontillado By Edgar Allan Poe1076 Words   |  5 PagesThe short story, The Cask of Amontillado, written by Edgar Allan Poe is a story of terror and betrayal. Like many of Poe’s literary works, the story has a dark undertone with a theme of terror and depression. More than half a century ago, Marshall McLuhan argued that though Poe was fascinated by evil, the evil that he had in mind was not that of Calvinism, but that of the split man and the split civilization. In general, McLuhan was right, but in this instance Calvinism, and its God, provided a darkRead MoreThe Cask Of Amontillado By Edgar Allan Poe707 Words   |  3 PagesIn the short story of The Ca sk of Amontillado, Edgar Allan Poe writes in first person point of view from the perspective of Montresor who seeks revenge against Fortunato. Montresor began to develop the perfect plan for revenge. During the carnival season, Montresor meets with Fortunato and decides to implement his plan carefully through irony. Poe s story describes the murderer s mind which has lived as a memory of Fortunato s death for fifty years. Poe uses different types of irony and symbolismRead MoreThe Cask Of Amontillado By Edgar Allan Poe985 Words   |  4 PagesEdgar Allen Poe is a well known author of short stories and poetry from the 19th century. He is known especially for his stories of horror and suspense. The Cask of Amontillado is one of his more famous pieces. The story follows the narrator, Montresor, as he exacts revenge on Fortunato. Montressor draws Fortunato into the wine cellar where eventually he chains Fortunato to the wall and encloses him inside it. Throughout the story the narrator continually proves that he is not the most reliable source

Spurring Impactful Research Systems †Free Samples to Students

Question: Discuss about the Spurring Impactful Research Systems. Answer: In terms of sustainability, the aim of LOreal is to give meaning to beauty. The company wants to share growth with the community (McKinnon et al., 2015). That means the company is providing increased attention to it surrounding communities, by developing projects that meet real social needs and that are consistent with the activities of the company. The company has taken an oath to reduce their carbon footprint by 60% within 2020 (L'Oral, 2017). However, despite of all the efforts, the company has to face two major issues related with sustainability. The most significant one is related with child labor. It has been found that mica is used as the glittery foundation for many cosmetic products developed by the company (L'Oral, 2017). It has been analyzed that 60% of this mineral used in LOreal is mined in India. Child labor is the dark side of this mining. Singh (2013) stated that child labor is global issue that affects many developing countries like India. According to Unicef, 13% ch ildren aged between 5 to 14 are entrenched in child labor. In India, 12-13% children aged between 5 to 14 years age is engaged in child labor (UNICEF, 2017). Since the mica mining is largely unregulated, there is high possibility of engagement of child labor in India. LOreal should take initiatives to reduce child labor in the mining industry of India. The second major issue that company is facing is related with attracting desirable customers. The company is still trying to find out a way to market products that have less impact on environment but still able to attract many customers (Malhotra et al., 2013). Recommendations for LOreal based on sustainability After analyzing the major issues of the company related with sustainability, it can be stated that the company can take initiatives to reduce child labor in India. There are some major steps, which the company can take to prohibit child labor in mica mining in India. They are such as: Develop a team and send it to India to develop a report on child labor in mica mining. They have to counsel those poor parents, who are sending their children to work. The taam must try to convince the parents of these children to not use them as domestic help. They need to make these parents understand the needs of sending their children to school. They have to make them understand that using children in work will not only destroy their childhood forever but also reduce their standard of living. It will become a generation wise tradition, if it is not stopped immediately. Report to the local authority, police and even to the labor minister when they find any evidence of using child labor. The team must have to encourage children to take participation in education instead of work. Phillips et al. (2014) stated that mind of child is highly impressionable. Leaving good impression on them and encourage them to have a big dream will encourage them to go to school. Finally, the company needs to make investment in India to develop schools for these poor children. References L'Oral - LOral Group. (2017). Loreal.com. Retrieved 1 May 2017, from https://www.loreal.com/ Malhotra, A., Melville, N. P., Watson, R. T. (2013). Spurring impactful research on information systems for environmental sustainability. MIS Quarterly, 37(4), 1265-1274. McKinnon, A., Browne, M., Whiteing, A., Piecyk, M. (Eds.). (2015). Green logistics: Improving the environmental sustainability of logistics. Kogan Page Publishers. Phillips, N., Bhaskaran, R., Nathan, D., Upendranadh, C. (2014). The social foundations of global production networks: towards a global political economy of child labour. Third World Quarterly, 35(3), 428-446. Singh, R. (2013). Child labour in India. Anusandhanika, 5(1/2), 44. UNICEF (2017). Unicef.org. Retrieved 1 May 2017, from https://www.unicef.org/

Women In Combat Essays (1962 words) - Gender Studies,

Women In Combat Women in Combat In the 1970's, the services traditional attitude toward women was challenged; change was forced upon a reluctant establishment (Holm, 198). The decision to end the draft was the catalyst to such change. This decision allowed for women's' participation in the armed forces in unprecedented numbers. The United States Armed Forces have more female numbers than any other nation in the world, both in actual numbers and in percentages (Holm, 1982). The drive for an all-volunteer force, along with an ?aggressive tide of feminism? and congressional passage of the equal rights Amendments led to a gradual shift in the role and status of women in the military (Holm, 1982). In today's military, women were no longer confined to traditional roles in the medical and administrative fields. Almost all military job categories and military occupational specialties (MOS) have been opened to women. They now repair tanks, warplanes, and intercontinental ballistic missiles (ICBM's). They serve on naval vess els that deploy to service ships and submarines of the operational fleet and on Coast Guard cutters operating off United States shores. They serve on missile crews, operate heavy equipment, and direct air traffic. They also provide essential support to combat troops in the field (Holm, 1982). It appears that women have been integrated into practically every aspect of the military; yet there are some jobs that remain closed to them, namely-direct combat specialties (Holm, 1982; Goldman, 1982). It is over these residual exclusions that controversy rages. Technically, women are barred by low or policy from what is defined in narrow terms as ?combat?. Each of the United States Armed Services excludes females from active Combat. The nature and extent of the exclusion varies with each service. Yet, many argue that the distinction between combat and non-combat becomes blurred in the context of women warfare (Gilder, 1979; Holm, 1982, Goldman, 1982). In actually, many women are assigned to jabs that will expose them to enemy attack, and this has been openly acknowledged by the top Pentagon officials (Women in combat-closer than you think, 1980). The United States Army has also recognized that women would be deployed in combat zones as an inevitable consequence of their assignments. This was confirmed in the following statement made by then Army Chief of Staff, General Bernad W. Rogers: ?Some people believe that women soldiers will not be deployed in the event of hostilities: that they are only to be part-time soldiers here in peace, gone i n war. Women are an essential part of the force; they will deploy with their units and they will serve in the skills in which they have been trained? (Holm, 1982, p. 286). It appears that the combat exclusion policy does not realistically exclude women from combat, and it seems the military's reliance on women is increasing. Schneider (1988) conducted interviews with women in traditionally male jobs, asking them what they felt their status would become if a war broke out. In general, they believed that they could not and would not be removed in combat situation? (p. 162). The following was taken from two of these interviews. ?I've already asked,? said a first flight engineer on a C-5, what happens if I'm sitting on alert in Europe somewhere and something really happens? Does that mean that they don't have a legal crew anymore because the engineer can't go' A Coast Guard female lieutenant had this to say: I was the trained CIC officer, responsible for the combat information center. Along with a team of radar men, CIC must plot all enemy and friendly forces and advise the bridge of such things as incoming missiles?. I'm the one that's used to working wi th these guys. That was the purpose of sending us through that simulated training, so that we could get used to working together as a team. What would they do? They couldn't just fly me off and stick somebody else in there?' (Schneider, 1988, p.162). It appears that the United States military is in a position where women are so fully and flexibly involved in the organizational structure, that in a war, it would be very difficult to separate them out. Yet, there are those who feel those women are not physically

Lightning Warning Signs You Shouldnt Ignore

Lightning Warning Signs You Shouldnt Ignore Nothing ruins a summer cookout, dip in the pool, or  camping trip  like a thunderstorm. If you are outdoors when a thunderstorm rolls up, it can be tempting  to stall as long as possible before going indoors. But how do you know when its time to stop what youre doing  and head inside? Keep a lookout for certain signs; theyll  warn you when its time to seek shelter indoors and when  lightning  may be about to strike. Signs of Lightning Cloud-to-ground lightning is nearby if you notice one or more of these early signs. Seek shelter immediately to reduce the risk of lightning injury or even death. A rapidly growing cumulonimbus cloud. Although cumulonimbus clouds appear  bright white and  form in sunny  skies,  dont be fooled- theyre the beginning stage of a developing thunderstorm. If you notice them growing taller and taller in the sky, you can rest assured that a storm is in the making and headed your way.Increasing winds  and a darkening sky.  These are telltale signs of an approaching storm.Audible thunder.  Thunder is the sound created by lightning, so if thunder can be heard, lightning is near. You can determine how near (in miles) by counting the number of seconds between a flash of lightning and a thunderclap and dividing that number by five.A severe thunderstorm warning.  The National Weather Service issues a severe thunderstorm warning whenever severe storms have been detected on weather radar  or confirmed by storm spotters. Cloud-to-ground lightning is often the  main threat of such storms. Lightning always occurs during thunderstorms, but it isnt necessary for a storm to be directly overhead for you  to be in danger of a lightning strike. The threat of lightning actually starts  as a thunderstorm approaches, peaks when the storm is overhead, and then gradually diminishes as the storm moves away. Where to Seek Shelter At the first sign of approaching lightning, you should quickly seek shelter, ideally in an enclosed building or other structure, away from windows. If youre at home, you may want to retreat to a central room or closet. If you cannot find shelter inside, the next best option is a vehicle with all of the windows rolled up. If for whatever reason, you are stuck outside, you should make sure to stand away from trees and other tall objects. Keep away from water and anything that is wet, as water is a strong conductor of electricity. Signs of an Immediate Strike When lightning strikes you or the area immediately nearby, you may experience one or more of these warning signs a few seconds beforehand. Hair standing  on endTingling skinA metallic taste in your mouthThe smell of chlorine  (this is ozone, which is produced when nitrogen oxides from lightning interact with other chemicals and sunlight)Sweaty palmsA vibrating, buzzing, or crackling sound coming from metal objects around you If you notice any of these signs, it may be too late to avoid being struck and possibly injured or killed. However,  if you find that you do have time to react, you should run as fast as you can to a safer location. Running limits the amount of time that both of your feet are on the ground at any given  moment, reducing the threat from ground current (lightning that travels outward from the strike point along the ground surface). Sources NOAA. NWS Lightning Safety Page.NOAA. NWS Weather Fatality, Injury, and Damage Statistics (2013, May 6).

10 Tips To Make Your First Tattoo Successful

10 Tips To Make Your First Tattoo Successful It may be clichà ©, but a tattoo is for life. You have no timetable. Before acting out, be sure that you are ready. Remember that you are continually evolving as a person. When you are about to get inked for life, consider that your tastes may not be the same in the future. For example, your tattoo of Britpop Blur group may not have the same effect in 10 years. Do not look for a discount. A tattoo is an investment. He will be there for several years, ideally. If you start looking for a discount, you may end up with a worse result than expected. Do your homework. Before going to see a tattoo artist, decide which style you like. Then search for artists who practice this technique. Then, do not hesitate to see them discuss what you want. They can advise you and help you make an informed choice. Choose the right moment. The temperature can significantly affect the healing process of your tattoo. Try to avoid the hot weather of the summer and the dry cold of the winter. Autumn and spring are the ideal moments. Listen to your tattoo artist. If the tattoo artist tells you that your drawing will not be beautiful once on your skin or that the location you have chosen is not ideal, trust him. He knows what he is doing. Prepare to get hurt.Yes, it hurts. Not a lot of pain, but still enough. Especially if the room you have taken is large enough. If you want, bring in headphones. Listening to music at the same time can help change the nonsense. Stay hydrated and feed. Getting a tattoo can be very physically demanding. Thats why its important to come to your appointment with a full stomach and a good thirst. We suggest you bring a bottle of water and a snack. Take care of your new tattoo Listen carefully to the instructions of your tattoo artist. During the first days, you have an open wound on your body. It is essential to clean it often with unscented soap. Once your tattoo has dried, create it as if your life depended on it. Avoid Polysporin or other disinfectants. Instead, favor moisturizing creams like Aveeno. You do not have to justify yourself to anyone. Once the tattoo is on your skin, it belongs to you. If you do not feel like talking about it, do not talk about it. It does not concern anyone except you.

Apple Watch and its luxury gambit Essay Example | Topics and Well Written Essays - 500 words

Apple Watch and its luxury gambit - Essay Example t it made its launching a disappointment to the many apple fans waiting for the product as they questioned what possible feature or reason would make them spend that amount of money. The watch comes with beautiful wrist bands that make them look like jewellery and a button that makes swiping of the screen easier, however, it was noted during the launch, there were confusing array of touches and buttons that were not as obvious as other apple devices. The launch of this watch was a disappointment to many because it did not meet the high standards people expected from it. Though there are many who appreciate and embrace the watch as it is, appreciating the features that come with it, the design and its uses, most people did not like the high prices associated with the new device and also how it did not have extra features from most smart phones as such. There are advantages of this commercialization. The market has had a chance to get to know the product. Apple’s creation of Healthkit in its operating system for the watch has brought a new feature where the consumer can keep track and record of health and fitness. The watch also receives data from smart phones and tablets-even though this is still restricted to the Apple ecosystem. The watch has a mobile payment services thus it can be used in transactions, just like a phone. It also has siri a personal assistant and it can control Apple TV. The risks related to commercialization of this watch outweigh the benefits. This is firstly, due to its very high prices announced when it was being launched. The prices seem to target a specific class of people. The other reason is due to its dependence to a smart phone- the watch cannot run on its own-just like the way apple phones share data with other apple phones only. (Lashinsky, 2012). However, there a few applications that can run independent of the smart phone like telling the time. Appropriate research and consideration of the target market did not seem to be put

Methodology Essay Example | Topics and Well Written Essays - 4750 words

Methodology - Essay Example In the training step, the characteristics will be derived from a recognized speaker sound then stored in a database that has a model or an outline like Password or Name. The stored information is then extracted by means of the model given by an unidentified speaker. The recovered data is then compared with characteristics extracted from the unidentified speaker sound. If the evaluation result is positive, then the unidentified speaker will be validated. The figure above 3.2.2 demonstrates two things: how the word will be accepted from the speakers voice as well as how to distinguish the personality of the speaker. The speech identification will need from the speaker to record the word. The classifier will be employed so as to extract the characteristics of the voice of the speaker and then the representation will be made and saved in the catalog. Just for the speaker identification the speakers voice will be recorded then features will be taken out and will be evaluated against the other speakers models so as to accept or reject the personality of a speaker. The figure above 3.2.3 demonstrates the enrollment along with verification phases, in the previous stage the speakers voice will be recorded so as to extract the attribute from his/her voice. After that, the replica will be created for every speaker word and will be stored it in the database. During the verification stage, the speaker’s voice will be recorded, and then the traits will be extorted from the speakers voice. After that, the choice will be made so as to accept or reject the speaker depending on the assessment of the extracted characteristic from a speaker along with the other recognized speaker models that were stored in the database. For this project, I employed Hidden Markov Model (HMM) for recognition of speech. 3.1 Hardware depiction: The software will be executed by means of some devices such as Microphone in addition to the computer, the microphone should

The Rise of the Byzantine Empire :: Education Essays

The Rise of the Byzantine Empire "What were some of the accomplishments of the Byzantine Empire?" Questions such as this one appear on the margins of sixth and seventh grade textbooks. What a better way of starting a new lesson or chapter than with questions that will automatically led the student to think about the answer? That is the case in the lesson of "The Rise of the Byzantine Empire." Being that the lesson I revised was only a brief part of the chapter, it was interesting to see how precise the lesson on the Rise of the Empire came about. There was nothing wrong with the format and structure of the lesson. When I fist glanced at the lesson I had received, I became very mortified to see that the lesson only consisted of 4 pages. Can the lesson on the rise of the Byzantine Empire really be described in 4 pages? I would not know that answer, unless I read the lesson, and did further research on the topic. Surprisingly, I discovered that the lesson is pretty much accurate, although it does not have much detail. Perhaps the detail is not very rich, because this lesson, (which is titled to be lesson 3) is a continuation of the study on Rome; it's emperors, etc. It is not to say that the lesson did not have weaknesses, however, it had both its strengths, and its weaknesses. Lesson 3, which is titled "The Rise of the Byzantine Empire," includes a timeline of the dates the certain lesson covers. In this case, the dates are from 532 A.D., to1453 A.D. Byzantium saw itself as the true descendent of Rome. In Byzanium many of the elements of Rome's cosmopolitan Mediterranean civilization continue. Gradually however, Greek replaces Latin as the primary language in both society and government, and distinctive social, political and cultural traditions emerge. The central figure in the revival of the power of Byzantium is the Emperor Justinian, from 527 to 565. The lesson was mainly focused on "the Byzantine Emperor Justinian." As the lesson starts, the story of how Justinian came about restoring order in the city of Constantinople is told in a brief summary of about 2 paragraphs. "Fights broke out between the rival groups, and the fighting escalated into rioting in Constantinople's streets. The rioting continued for a week while Justinian and Theodora, safe withi n their palace, debated whether to flee or to attempt to restore order.

Homework Assignment Essay

1.Prepare an analysis of the automobile manufacturing industry using Porter’s five forces framework. For each component force provide support for your conclusion. In addition, at the completion of your analysis provide a conclusion, along with support, of whether you expect the automobile industry to report high or low profitability in the near future. 2. Tremble Company manufactures outdoors wear for women. During 2009, the company reported the following items that affected cash. Required: Indicate whether each of these items is a cash flow from operating activities (O), investing activities (I), or financing activities (F). A. Paid cash for supplies B. Purchased equipment by paying cash C. Collected cash on account from customers D. Paid dividends to stockholders E. Paid suppliers for fabric F. Borrowed money from a bank on a long-term note G. Paid interest to bank on the note H. Paid wages to employees I. Sold shares of common stock to new stockholders 3. The following selected financial data pertain to four companies: a hotel, a travel agency, a meat packing company and a pharmaceutical company. Required: Match each with the financial information and explain why you made your choice as you did. Balance Sheet Data (component percentages)Company 1Company 2Company 3Company 4 Cash7.222.06.011.2 Accounts Receivable28.040.03.423.0 Inventory21.40.50.927.4 Property, Plant & Equipment 32.019.075.125.0 Income Statement Data (component percentages) Gross Profit15.2Not ApplicableNot Applicable44.0 Profit before Taxes1.83.32.57.0 Ratios Current ratio (over the last five years)1.61.30.51.8 Inventory turnover ratio27.8Not ApplicableNot Applicable 3.4 Debt-to-equity ratio1.82.35.81.4 4. Use the current asset section of the balance sheets of the El Paso Company as of January 31, 2012 and 2011 presented below to answer the questions that follow. 2012 2011 Cash and cash equivalents$ 75,000$ 58,800 Trade accounts receivable, net 157,500 193,200 Inventory 208,200 253,400 Other current assets 18,400 15,500 Total current assets$ 459,100$ 520,900 Total assets$2,650,000$3,430,000 Required: (a) In the spaces provided below, complete a Percentage Change analysis of the current asset section of El Paso Company’s balance sheet for 2012, using the following format to provide your answers for the amount of dollar change and the amount of percentage change, rounding â€Å"% Change† to one decimal place, e.g., 8.3%. Accounts$ Change% Change (b) Provide a short evaluation of this analysis.

Francis Simonh M. Bries (2012-24817, Ma Psychology)....

Francis Simonh M. Bries (2012-24817, MA Psychology) Psychology 282: Reflections—A Theory of Heuristic and Systematic Information Processing 14 February 2017 Heuristic and Systematic Processing: When Do People Think? As opposed to attribution theory s emphasis on human rationality in the search for the causes of behavior, the theory of heuristic and systematic information processing takes a stance on the opposite end: Humans, with all things being equal, could not be bothered to think deeper than what can be concluded using learned shortcuts and easily accessed information. The latter heuristic processing is preferred in most situations as it does not require cognitive effort because of its automaticity yet nevertheless arriving at†¦show more content†¦No matter how much voters are requested to use information, conscience, or whatever form of rationality to decide on matter of national interest, an uninformed and unmotivated electorate would always resort to emotional appeals, endorsements, and easily accessible cues—as predicted by the theory. Perhaps, even when extreme accuracy is required by the situation, the motivation to consider information systematically more significantly determines when people would engage in the latter. As such, the current theory would come as an unpleasant surprise to people who obstinately cling to their hopes on the absolute rationality of humanity. With the theory developed within Western psychology and their culture’s history of the Enlightenment, scientific thinking, and philosophical introspection, the notion of an automatic heuristic process operating separately from more conscious cognition appears unacceptable. However, some of the heuristic cues introduced in the attitude studies that served as the basis of the theory may be acceptable for collectivist cultures. Factors such as audience response and consensus information are inherently central to cultures where interdependence and unified perspectives are expected (i.e. that the perspectives of one’s community must be considered alongside one’s own). As such, whereas an individualist culture would cite these variables as